Effect of pregnancy on hyperthyroidism

Graves' disease will tend to go into partial remission during pregnancy. However, treatment will still be required in almost all cases, even though for those already on treatment, the dose may have to be reduced. Delivery is usually followed by exacerbation of the condition.

Prapylthiouracil (PTU) and breast-feeding

The use of PTU does not preclude breast-feeding. Even though a very small amount of the drug is found in breast-milk, it is not considered to be in sufficient quantities to cause unwanted effects.

Carbimazole and breast-feeding

Use of Carbimazole too does not preclude breastfeeding. The advice is actually similar as for PTU above. The lowest effective dose should be used and the baby's growth progress monitored.

"Thyroid storm"and pregnancy

Thyroid storm is a rare complication of hyperthyroidism. It may be triggered by infection, labor or surgery (such as cesarean section). It may also complicate surgery undertaken to treat the disease itself.

It is a result of a release of massive quantities of the thyroid hormone into the bloodstream. It is characterized by a very high temperature, high heart rate (and palpitations), dehydration and extreme agitation.

Effects of thyroid storm

Thyroid storm is a dangerous condition. Intensive and sustained efforts to control the symptoms and suppress the thyroid hormone are required. When appropriately managed, the condition is brought under control in a relatively short time.

Hyperthyroidism and excessive vomiting

In a small proportion of women who suffer excessive nausea and vomiting in early pregnancy, hyperthyroidism is found to be the associated factor. Control of the hyperthyroidism is usually followed by subsiding of the nausea and vomiting. It is, however, not a common cause of vomiting in pregnancy. Most mothers presenting with excessive nausea and vomiting in early pregnancy have normal thyroid function.

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